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Article

SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells.

Free radical biology & medicine - 15 Sept 2011

Koyama Tetsuro, Kume Shinji, Koya Daisuke, Araki Shin-ichi, Isshiki Keiji, Chin-Kanasaki Masami, Sugimoto Toshiro, Haneda Masakazu, Sugaya Takeshi, Kashiwagi Atsunori, Maegawa Hiroshi, Uzu Takashi

Abstract excerpt

Free fatty acid (FFA)-mediated renal lipotoxicity is associated with the progression of tubulointerstitial inflammation in proteinuric kidney disease. SIRT3 is an antiaging molecule regulated by calorie restriction and mitochondria-localized NAD(+)-dependent deacetylase. In this study, we investigated whether SIRT3 reversed renal lipotoxicity-mediated ROS and inflammation. In the kidney of the FFA-bound...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21664458
DOI: 10.1016/j.freeradbiomed.2011.05.028

Genes

SIRT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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