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Genetic and gene expression studies implicate renin and endothelin-1 in edema caused by peroxisome proliferator-activated receptor gamma agonists.

Pharmacogenetics and genomics - 1 Oct 2008

Geese William J, Achanzar William, Rubin Cindy, Hariharan Narayanan, Cheng Peter, Tomlinson Lindsay, Ordway Nicole, Dracopoli Nicholas C, Delmonte Terrye, Hui Lester, Krishnan Bala, Cosma Greg, Ranade Koustubh

Abstract excerpt

OBJECTIVE: Peroxisome proliferator-activated receptor gamma (PPARgamma) agonists can cause peripheral edema in susceptible individuals. To investigate the mechanistic basis underlying this adverse event, we performed a candidate gene analysis of patients enrolled in clinical trials of muraglitazar, an investigational PPARalpha/gamma dual agonist, and developed a cell culture-based gene expression assay and...

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PMID: 18794727
DOI: 10.1097/FPC.0b013e32830a6ea0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Genetic and gene expression studies implicate renin and endothelin-1 in edema caused by peroxisome proliferator-activated receptor gamma agonists.PMID 18794727Read ↗

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