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Article

Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency.

The Journal of clinical investigation - 1 Feb 2000

Miles P D, Barak Y, He W, Evans R M, Olefsky J M

Abstract excerpt

The thiazolidinedione class of insulin-sensitizing, antidiabetic drugs interacts with peroxisome proliferator-activated receptor gamma (PPAR-gamma). To gain insight into the role of this nuclear receptor in insulin resistance and diabetes, we conducted metabolic studies in the PPAR-gamma gene knockout mouse model. Because homozygous PPAR-gamma-null mice die in development, we studied glucose metabolism in mice...

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Identifiers

PMID: 10675354
DOI: 10.1172/JCI8538
PMCID: PMC377448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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