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Article

Interaction between blood lead concentration and delta-amino-levulinic acid dehydratase gene polymorphisms increases the odds of essential tremor.

Movement disorders : official journal of the Movement Disorder Society - 1 Sept 2005

Louis Elan D, Applegate Lakeisha, Graziano Joseph H, Parides Michael, Slavkovich Vesna, Bhat Hari K

Abstract excerpt

Blood lead (BPb) concentrations are elevated in essential tremor (ET) cases. The delta-amino-levulinic acid dehydratase (ALAD) gene codes for ALAD, the principal enzyme involved in lead kinetics. Carriers of the ALAD-2 allele may be more susceptible to lead toxicity. The objective of this study was to test, using a case-control design, whether an interaction between BPb concentration and ALAD allele status...

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Source

Identifiers

PMID: 15954127
DOI: 10.1002/mds.20565

Genes

ALAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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