Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic susceptibility of δ-ALAD associated with lead (Pb) intoxication: sources of exposure, preventive measures, and treatment interventions.

Environmental science and pollution research international - 1 Sept 2021

Qader Abdul, Rehman Kanwal, Akash Muhammad Sajid Hamid

Abstract excerpt

Delta-aminolevulinic acid dehydratase (δ-ALAD) is involved in the synthesis of haem and exhibits a polymorphic nature. δ-ALAD polymorphism produces two alleles, namely δ-ALAD-1 and δ-ALAD-2, which in turn produce three different phenotypes, namely δ-ALAD1-1, δ-ALAD1-2, and δ-ALAD2-2. δ-ALAD gene is more susceptible to lead (Pb) toxicity than any other genes. Its genotype and phenotype frequencies change with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Predisposition to Disease
Share to Lead

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Occupational Exposure

Share to Polymorphism, Genetic

Share to Porphobilinogen Synthase

Source

Identifiers

PMID: 34244947
DOI: 10.1007/s11356-021-15323-1

Genes

ALAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic susceptibility of δ-ALAD associated with lead (Pb) intoxication: sources of exposure, preventive measures, and treatment interventions.PMID 34244947Read ↗

Modifying effects of δ-Aminolevulinate dehydratase polymorphism on blood lead levels and ALAD activity.Semantic proximity Read ↗

Delta-aminolevulinic acid dehydratase genotype and lead toxicity: a HuGE review.Semantic proximity Read ↗

Lead and delta-aminolevulinic acid dehydratase polymorphism: where does it lead? A meta-analysis.Semantic proximity Read ↗

Use of Generalized Additive Model to Detect the Threshold of δ-Aminolevulinic Acid Dehydratase Activity Reduced by Lead Exposure.Semantic proximity Read ↗

Investigation of delta-aminolevulinic acid dehydratase polymorphism affecting hematopoietic, hepatic and renal toxicity from lead in Han subjects of southwestern China.Semantic proximity Read ↗

δ-Aminolevulinic acid dehydratase genotype predicts toxic effects of lead on workers' peripheral nervous system.Semantic proximity Read ↗

Genetic susceptibility to low-level lead exposure in men: Insights from ALAD polymorphisms.Semantic proximity Read ↗

Relationship between delta-aminolevulinic acid dehydratase genotypes and heme precursors in lead workers.Semantic proximity Read ↗

Association between a polymorphism of aminolevulinate dehydrogenase (ALAD) gene and blood lead levels in Japanese subjects.Semantic proximity Read ↗

Association between delta-aminolevulinic acid dehydratase (ALAD) polymorphism and blood lead levels: a meta-regression analysis.Semantic proximity Read ↗

Maternal Δ-aminolevulinic acid dehydratase 1-2 genotype enhances fetal lead exposure and increases the susceptibility to the development of cerebral palsy.Semantic proximity Read ↗

The protective effect of delta-aminolevulinic acid dehydratase 1-2 and 2-2 isozymes against blood lead with higher hematologic parameters.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.