Genetic susceptibility of δ-ALAD associated with lead (Pb) intoxication: sources of exposure, preventive measures, and treatment interventions.

doi:10.1007/s11356-021-15323-1

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Article

Genetic susceptibility of δ-ALAD associated with lead (Pb) intoxication: sources of exposure, preventive measures, and treatment interventions.

Environmental science and pollution research international - 1 Sept 2021

Qader Abdul, Rehman Kanwal, Akash Muhammad Sajid Hamid

Abstract excerpt

Delta-aminolevulinic acid dehydratase (δ-ALAD) is involved in the synthesis of haem and exhibits a polymorphic nature. δ-ALAD polymorphism produces two alleles, namely δ-ALAD-1 and δ-ALAD-2, which in turn produce three different phenotypes, namely δ-ALAD1-1, δ-ALAD1-2, and δ-ALAD2-2. δ-ALAD gene is more susceptible to lead (Pb) toxicity than any other genes. Its genotype and phenotype frequencies change with...

Topics

Genetic Predisposition to Disease
Humans
Lead
Lead Poisoning
Occupational Exposure
Polymorphism, Genetic
Porphobilinogen Synthase

Source

Open in PubMed

Identifiers

PMID: 34244947
DOI: 10.1007/s11356-021-15323-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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