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Article

Delta-aminolevulinic acid dehydratase genotype and lead toxicity: a HuGE review.

American journal of epidemiology - 1 Jul 2001

Kelada S N, Shelton E, Kaufmann R B, Khoury M J

Abstract excerpt

The ALAD gene (chromosome 9q34) codes for delta-aminolevulinic acid dehydratase (ALAD) (E.C. 4.2.1.24). ALAD catalyzes the second step of heme synthesis and is polymorphic. The ALAD G177C polymorphism yields two codominant alleles, ALAD-1 and ALAD-2, and it has been implicated in susceptibility to lead toxicity. Genotype frequencies vary by geography and race. The rarer ALAD-2 allele has been associated with high...

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Source

Identifiers

PMID: 11427399
DOI: 10.1093/aje/154.1.1

Genes

ALAD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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