δ-Aminolevulinic acid dehydratase genotype predicts toxic effects of lead on workers' peripheral nervous system.

doi:10.1016/j.neuro.2011.03.006

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δ-Aminolevulinic acid dehydratase genotype predicts toxic effects of lead on workers' peripheral nervous system.

Neurotoxicology - 1 Aug 2011

Zheng Guang, Tian Liting, Liang Yihuai, Broberg Karin, Lei Lijian, Guo Weijun, Nilsson Johan, Bergdahl Ingvar A, Skerfving Staffan, Jin Taiyi

Abstract excerpt

There is a wide variation in sensitivity to lead (Pb) exposure, which may be due to genetic susceptibility towards Pb. We investigated whether a polymorphism (rs1800435) in the δ-aminolevulinic acid dehydratase (ALAD) gene affected the toxicokinetics and toxicodynamics of Pb. Among 461 Chinese Pb-exposed storage battery and 175 unexposed workers, allele frequencies for the ALAD1 and ALAD2 alleles were 0.968 and...

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PMID: 21439310
DOI: 10.1016/j.neuro.2011.03.006

Genes

ALAD
VDR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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