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Article

Elevated blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations in essential tremor.

Neurotoxicology - 1 Mar 2008

Louis Elan D, Jiang Wendy, Pellegrino Kathryn M, Rios Eileen, Factor-Litvak Pam, Henchcliffe Claire, Zheng Wei

Abstract excerpt

Essential tremor (ET) is a widespread late-life neurological disease. Genetic and environmental factors likely play an etiological role. Harmane (1-methyl-9H-pyrido[3,4-b]indole) is a potent tremor-producing neurotoxin. In 2002, we demonstrated elevated blood harmane concentrations in an initial sample of 100 ET cases compared to 100 controls. Between 2002 and 2007, we assembled a new and larger sample of ET...

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Identifiers

PMID: 18242711
DOI: 10.1016/j.neuro.2007.12.001
PMCID: PMC2291546

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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