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Article

Modifying effects of δ-Aminolevulinate dehydratase polymorphism on blood lead levels and ALAD activity.

Toxicology letters - 1 Oct 2018

Mani Monica Shirley, Kunnathully Vidya, Rao Chaitra, Kabekkodu Shama Prasada, Joshi Manjunath B, D'Souza Herman Sunil

Abstract excerpt

Lead is an environmental hazard with great public health concern and has been known to inhibit delta-aminolevulinate dehydratase (ALAD) activity involved in the heme biosynthetic pathway. The study aimed to investigate the influence of ALAD polymorphism (G177C) on retention of Pb-B levels and ALAD activity on occupationally exposed lead workers. In the present study, we enrolled 561 lead exposed and 317...

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Identifiers

PMID: 30025905
DOI: 10.1016/j.toxlet.2018.07.014

Genes

ALAD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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