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Article

Role of human DNA2 (hDNA2) as a potential target for cancer and other diseases: A systematic review.

DNA repair - 1 Nov 2017

Jia Pan-Pan, Junaid Muhammad, Ma Yan-Bo, Ahmad Farooq, Jia Yong-Fang, Li Wei-Guo, Pei De-Sheng

Abstract excerpt

DNA nuclease/helicase 2 (DNA2), a multi-functional protein protecting the high fidelity of genomic transmission, plays critical roles in DNA replication and repair processes. In the maturation of Okazaki fragments, DNA2 acts synergistically with other enzymes to cleave the DNA-RNA primer flaps via different pathways. DNA2 is also involved in the stability of mitochondrial DNA and the maintenance of telomeres....

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Identifiers

PMID: 28903076
DOI: 10.1016/j.dnarep.2017.09.001

Genes

DNA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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