Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of human DAAO variants potentially related to an increased risk of schizophrenia.

Biochimica et biophysica acta - 1 Mar 2013

Caldinelli Laura, Sacchi Silvia, Molla Gianluca, Nardini Marco, Pollegioni Loredano

Abstract excerpt

Considering the key role of d-serine in N-methyl-d-aspartate receptor-mediated neurotransmission, it is highly relevant to define the role that enzymes play in d-serine synthesis and degradation. In particular, the details of regulation of the d-serine catabolic human enzyme d-amino acid oxidase (hDAAO) are unknown although different lines of evidence have shown it to be involved in schizophrenia susceptibility....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caspases
Share to Circular Dichroism
Share to Enzyme Stability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Flavin-Adenine Dinucleotide

Share to Microscopy, Confocal

Share to Mutant Proteins

Share to Protein Structure, Quaternary

Share to Serine

Source

Identifiers

PMID: 23219954
DOI: 10.1016/j.bbadis.2012.11.019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of human DAAO variants potentially related to an increased risk of schizophrenia.PMID 23219954Read ↗

Structure-function relationships in human d-amino acid oxidase variants corresponding to known SNPs.Semantic proximity Read ↗

Elucidating the role of the pLG72 R30K substitution in schizophrenia susceptibility.Semantic proximity Read ↗

Structure-function relationships in human d-aspartate oxidase: characterisation of variants corresponding to known single nucleotide polymorphisms.Semantic proximity Read ↗

The neurobiology of D-amino acid oxidase and its involvement in schizophrenia.Semantic proximity Read ↗

Structural and mechanistic insights into ALS patient derived mutations in D-amino acid oxidase.Semantic proximity Read ↗

d-Amino Acids and pLG72 in Alzheimer's Disease and Schizophrenia.Semantic proximity Read ↗

D-amino acid oxidase activator gene (DAOA) variation affects cerebrospinal fluid homovanillic acid concentrations in healthy Caucasians.Semantic proximity Read ↗

DNA methylation landscape of the genes regulating D-serine and D-aspartate metabolism in post-mortem brain from controls and subjects with schizophrenia.Semantic proximity Read ↗

D-Serine: Potential Therapeutic Agent and/or Biomarker in Schizophrenia and Depression?Semantic proximity Read ↗

Identification of multiple serine racemase (SRR) mRNA isoforms and genetic analyses of SRR and DAO in schizophrenia and D-serine levels.Semantic proximity Read ↗

Characterization of E121K mutation of D-amino acid oxidase - Insights into mechanisms leading to amyotrophic lateral sclerosis.Semantic proximity Read ↗

Reviewing the role of the genes G72 and DAAO in glutamate neurotransmission in schizophrenia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.