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Article

Drosophila Nesprin-1 Isoforms Differentially Contribute to Muscle Function.

Cells - 6 Nov 2021

Rey Alexandre, Schaeffer Laurent, Durand Bénédicte, Morel Véronique

Abstract excerpt

Nesprin-1 is a large scaffold protein connecting nuclei to the actin cytoskeleton via its KASH and Calponin Homology domains, respectively. Nesprin-1 disconnection from nuclei results in altered muscle function and myonuclei mispositioning. Furthermore, Nesprin-1 mutations are associated with muscular pathologies such as Emery Dreifuss muscular dystrophy and arthrogryposis. Nesprin-1 was thus proposed to mainly...

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Identifiers

PMID: 34831284
DOI: 10.3390/cells10113061
PMCID: PMC8616381

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