Article
Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin.
Journal of cell science - 1 Jun 2008
Lüke Yvonne, Zaim Hafida, Karakesisoglou Iakowos, Jaeger Verena M, Sellin Lorenz, Lu Wenshu, Schneider Maria, Neumann Sascha, Beijer Asa, Munck Martina, Padmakumar V C, Gloy Joachim, Walz Gerd, Noegel Angelika A
Abstract excerpt
Giant isoforms, encoded by Nesprin-1 (Syne1) and Nesprin-2 (Syne2), are multifunctional actin-binding and nuclear-envelope-associated proteins belonging to the spectrin superfamily. Here, we investigate the function of Nesprin-2 Giant (NUANCE) in skin by generating mice lacking the actin-binding domain of Nesprin-2 (Nesprin-2DeltaABD). This loss results in a slight but significant thickening of the epidermis,...
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