Article
Lamin A/C-dependent localization of Nesprin-2, a giant scaffolder at the nuclear envelope.
Molecular biology of the cell - 1 Jul 2005
Libotte Thorsten, Zaim Hafida, Abraham Sabu, Padmakumar V C, Schneider Maria, Lu Wenshu, Munck Martina, Hutchison Christopher, Wehnert Manfred, Fahrenkrog Birthe, Sauder Ursula, Aebi Ueli, Noegel Angelika A, Karakesisoglou Iakowos
Abstract excerpt
The vertebrate proteins Nesprin-1 and Nesprin-2 (also referred to as Enaptin and NUANCE) together with ANC-1 of Caenorhabditis elegans and MSP-300 of Drosophila melanogaster belong to a novel family of alpha-actinin type actin-binding proteins residing at the nuclear membrane. Using biochemical techniques, we demonstrate that Nesprin-2 binds directly to emerin and the C-terminal common region of lamin A/C....
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