Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

AIP4 restricts transforming growth factor-beta signaling through a ubiquitination-independent mechanism.

The Journal of biological chemistry - 29 Jul 2005

Lallemand François, Seo Su Ryeon, Ferrand Nathalie, Pessah Marcia, L'Hoste Sebastien, Rawadi Georges, Roman-Roman Sergio, Camonis Jacques, Atfi Azeddine

Abstract excerpt

Smad7 functions as an intracellular antagonist in transforming growth factor-beta (TGF-beta) signaling. In addition to interacting stably with the activated TGF-beta type I receptor (TbetaRI) to prevent phosphorylation of the receptor-regulated Smads (Smad2 and Smad3), Smad7 also induces degradation of the activated TbetaRI through association with different E3 ubiquitin ligases. Using the two-hybrid screen, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalysis
Share to COS Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoblotting

Share to Immunoprecipitation

Share to Smad7 Protein

Share to Transforming Growth Factor beta

Share to Two-Hybrid System Techniques

Share to Ubiquitin

Source

Identifiers

PMID: 15946939
DOI: 10.1074/jbc.M500188200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AIP4 restricts transforming growth factor-beta signaling through a ubiquitination-independent mechanism.PMID 15946939Read ↗

Current perspectives on inhibitory SMAD7 in health and diseaseSemantic proximity Read ↗

USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor.Semantic proximity Read ↗

AMBRA1 Promotes TGFβ Signaling via Nonproteolytic Polyubiquitylation of Smad4.Semantic proximity Read ↗

Inhibitory Smad7: Emerging Roles in Health and DiseaseSemantic proximity Read ↗

Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases.Semantic proximity Read ↗

Control of Smad7 stability by competition between acetylation and ubiquitination.Semantic proximity Read ↗

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia.Semantic proximity Read ↗

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation.Semantic proximity Read ↗

Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain.Semantic proximity Read ↗

Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity.Semantic proximity Read ↗

The balance of cell surface and soluble type III TGF-β receptor regulates BMP signaling in normal and cancerous mammary epithelial cells.Semantic proximity Read ↗

Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.