Article
Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain.
Molecular cell - 5 Aug 2005
Ogunjimi Abiodun A, Briant Douglas J, Pece-Barbara Nadia, Le Roy Christine, Di Guglielmo Gianni M, Kavsak Peter, Rasmussen Richele K, Seet Bruce T, Sicheri Frank, Wrana Jeffrey L
Abstract excerpt
The conjugation of ubiquitin to proteins involves a cascade of activating (E1), conjugating (E2), and ubiquitin-ligating (E3) type enzymes that commonly signal protein destruction. In TGFbeta signaling the inhibitory protein Smad7 recruits Smurf2, an E3 of the C2-WW-HECT domain class, to the TGFbeta receptor complex to facilitate receptor degradation. Here, we demonstrate that the amino-terminal domain (NTD) of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.