Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

AMBRA1 Promotes TGFβ Signaling via Nonproteolytic Polyubiquitylation of Smad4.

Cancer research - 1 Oct 2021

Liu Jinquan, Yuan Bo, Cao Jin, Luo Hongjie, Gu Shuchen, Zhang Mengdi, Ding Ran, Zhang Long, Zhou Fangfang, Hung Mien-Chie, Xu Pinglong, Lin Xia, Jin Jianping, Feng Xin-Hua

Abstract excerpt

Transforming growth factor β (TGFβ) is prometastatic in advanced cancers and its biological activities are mainly mediated by the Smad family of proteins. Smad4 is the central signal transducer and transcription factor in the TGFβ pathway, yet the underlying mechanisms that govern transcriptional activities of Smad4 are not fully understood. Here, we show that AMBRA1, a member of the DDB1 and CUL4-associated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockdown Techniques

Share to Heterografts

Share to Smad4 Protein

Share to Substrate Specificity

Share to Transforming Growth Factor beta

Share to Ubiquitination

Source

Identifiers

PMID: 34362797
DOI: 10.1158/0008-5472.CAN-21-0431

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AMBRA1 Promotes TGFβ Signaling via Nonproteolytic Polyubiquitylation of Smad4.PMID 34362797Read ↗

DEAR1 Is a Chromosome 1p35 Tumor Suppressor and Master Regulator of TGF-β–Driven Epithelial–Mesenchymal TransitionSemantic proximity Read ↗

The four and a half LIM-only protein 2 (FHL2) activates transforming growth factor β (TGF-β) signaling by regulating ubiquitination of the E3 ligase Arkadia.Semantic proximity Read ↗

The immune regulation and therapeutic potential of the SMAD gene family in breast cancerSemantic proximity Read ↗

The Post-translational Modifications of Smurf2 in TGF-β SignalingSemantic proximity Read ↗

BFAR coordinates TGFβ signaling to modulate Th9-mediated cancer immunotherapySemantic proximity Read ↗

The Smads.Semantic proximity Read ↗

USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor.Semantic proximity Read ↗

Monoubiquitination of p120-catenin is essential for TGFβ-induced epithelial-mesenchymal transition and tumor metastasisSemantic proximity Read ↗

The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathwaySemantic proximity Read ↗

AIP4 restricts transforming growth factor-beta signaling through a ubiquitination-independent mechanism.Semantic proximity Read ↗

How ubiquitination regulates the TGF‐β signalling pathway: New insights and new playersSemantic proximity Read ↗

USP11 Enhances TGFβ-Induced Epithelial–Mesenchymal Plasticity and Human Breast Cancer MetastasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.