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Article

USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor.

Nature cell biology - 17 Jun 2012

Zhang Long, Zhou FangFang, Drabsch Yvette, Gao Rui, Snaar-Jagalska B Ewa, Mickanin Craig, Huang Huizhe, Sheppard Kelly-Ann, Porter Jeff A, Lu Chris X, ten Dijke Peter

Abstract excerpt

The stability and membrane localization of the transforming growth factor-β (TGF-β) type I receptor (TβRI) determines the levels of TGF-β signalling. TβRI is targeted for ubiquitylation-mediated degradation by the SMAD7-SMURF2 complex. Here we performed a genome-wide gain-of-function screen and i...

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Source

Identifiers

PMID: 22706160
DOI: 10.1038/ncb2522

Genes

USP4
SMAD7
SMURF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22706160-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor.PMID 22706160Read ↗

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