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Article

Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity.

Science (New York, N.Y.) - 11 Mar 2005

Ozdamar Barish, Bose Rohit, Barrios-Rodiles Miriam, Wang Hong-Rui, Zhang Yue, Wrana Jeffrey L

Abstract excerpt

The transition of cells from an epithelial to a mesenchymal phenotype is a critical event during morphogenesis in multicellular organisms and underlies the pathology of many diseases, including the invasive phenotype associated with metastatic carcinomas. Transforming growth factor beta (TGFbeta) is a key regulator of epithelial-to-mesenchymal transition (EMT). However, the molecular mechanisms that control the...

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PMID: 15761148
DOI: 10.1126/science.1105718

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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