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Article

Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane.

The Journal of biological chemistry - 18 Oct 2002

Suzuki Chie, Murakami Gyo, Fukuchi Minoru, Shimanuki Tomomasa, Shikauchi Yuko, Imamura Takeshi, Miyazono Kohei

Abstract excerpt

Smad ubiquitin regulatory factor 1 (Smurf1), a HECT-type E3 ubiquitin ligase, interacts with inhibitory Smad7 and induces cytoplasmic localization of Smad7. Smurf1 then associates with transforming growth factor-beta type I receptor (TbetaR-I) and enhances the turnover of this receptor. However, the mechanisms of the nuclear export and plasma membrane localization of the Smurf1.Smad7 complex have not been...

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Identifiers

PMID: 12151385
DOI: 10.1074/jbc.M201901200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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