Article
Control of Smad7 stability by competition between acetylation and ubiquitination.
Molecular cell - 1 Sept 2002
Grönroos Eva, Hellman Ulf, Heldin Carl-Henrik, Ericsson Johan
Abstract excerpt
Smad proteins regulate gene expression in response to TGFbeta signaling. Here we present evidence that Smad7 interacts with the transcriptional coactivator p300, resulting in acetylation of Smad7 on two lysine residues in its N terminus. Acetylation or mutation of these lysine residues stabilizes Smad7 and protects it from TGFbeta-induced degradation. Furthermore, we demonstrate that the acetylated residues in...
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