Article
Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia.
The EMBO journal - 19 Apr 2006
Liu Wei, Rui Hongliang, Wang Jifeng, Lin Shuyong, He Ying, Chen Mingliang, Li Qinxi, Ye Zhiyun, Zhang Suping, Chan Siu Chiu, Chen Ye-Guang, Han Jiahuai, Lin Sheng-Cai
Abstract excerpt
TGF-beta signaling involves a wide array of signaling molecules and multiple controlling events. Scaffold proteins create a functional proximity of signaling molecules and control the specificity of signal transduction. While many components involved in the TGF-beta pathway have been elucidated, little is known about how those components are coordinated by scaffold proteins. Here, we show that Axin activates...
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