Identification of key residues in the amino-terminal third of human interleukin-1 alpha.

Article

Identification of key residues in the amino-terminal third of human interleukin-1 alpha.

The Journal of biological chemistry - 5 Aug 1990

Yanofsky S D, Zurawski G

Abstract excerpt

Two mutational approaches were used to perform a thorough structure-function analysis of the first 53 residues of the 159-residue cytokine human interleukin-1 alpha (hIL-1 alpha). In this study, a total of 26 deletions, 97 multiple amino acid substitutions, and 46 single amino acid substitutions...

Topics

Amino Acid Sequence
Animals
Base Sequence
Chromosome Deletion
Escherichia coli
Genes, Synthetic
Genetic Vectors
Humans
Immunoblotting
Interleukin-1
Molecular Sequence Data
Mutation
Plasmids
Sequence Homology, Nucleic Acid

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