Is sequence conservation in interferons due to selection for functional proteins?

doi:10.1038/313698a0

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Article

Is sequence conservation in interferons due to selection for functional proteins?

Nature - 1 Jan 2000

Valenzuela D, Weber H, Weissmann C

Abstract excerpt

The human alpha-interferon (IFN-alpha) gene family consists of at least 14 potentially functional non-allelic members; the amino acid sequences they encode differ from each other by up to approximately 20% of their residues. Human IFN-beta, which is encoded by a single gene, is distantly related...

Topics

Amino Acid Sequence
Genetic Engineering
Humans
Interferon Type I
Mutation
Plasmids
Structure-Activity Relationship

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