Article
v-Fps-responsiveness in the Egr-1 promoter is mediated by serum response elements.
Nucleic acids research - 11 May 1992
Alexandropoulos K, Qureshi S A, Rim M, Sukhatme V P, Foster D A
Abstract excerpt
Egr-1, a mitogen-responsive transcription factor, is rapidly induced by v-Fps in the absence of protein synthesis. Thus, Egr-1 is a primary response to the protein-tyrosine kinase activity of v-Fps. To determine the v-Fps-responsive elements in the Egr-1 promoter, deletion mutants of the Egr-1 pr...
Topics
- 3T3 Cells
- Animals
- Cell Line
- DNA-Binding Proteins
- Early Growth Response Protein 1
- Fusion Proteins, gag-onc
- Gene Expression Regulation
- Immediate-Early Proteins
- Mice
- Mutation
- Nuclear Proteins
- Plasmids
- Promoter Regions, Genetic
- Protein-Tyrosine Kinases
- Rats
- Serum Response Factor
- Transcription Factors
- Transfection