Ha-Ras functions downstream from protein kinase C in v-Fps-induced gene expression mediated by TPA response elements.

Article

Ha-Ras functions downstream from protein kinase C in v-Fps-induced gene expression mediated by TPA response elements.

Oncogene - 1 Mar 1993

Alexandropoulos K, Qureshi S A, Foster D A

Abstract excerpt

v-Fps activates promoters under the control of the 12-O-tetradecanoyl phorbol 13-acetate (TPA) response element (TRE). The induction of TRE-mediated transcription by v-Fps was sensitive to a dominant-negative mutant of Ha-Ras. An activated derivative of Ha-Ras, v-Ha-Ras, also activated TRE-mediat...

Topics

3T3 Cells
Animals
Chloramphenicol O-Acetyltransferase
Fusion Proteins, gag-onc
GTP-Binding Proteins
Gene Expression Regulation
Genes, ras
Mice
Mutation
Protein Kinase C
Protein-Tyrosine Kinases
Tetradecanoylphorbol Acetate

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