Article
The induction of Egr-1 expression by v-Fps is via a protein kinase C-independent intracellular signal that is sequentially dependent upon HaRas and Raf-1.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Oct 1992
Alexandropoulos K, Qureshi S A, Bruder J T, Rapp U, Foster D A
Abstract excerpt
Activating the protein-tyrosine kinase activity of v-Fps leads to the rapid transcriptional activation of the Egr-1 gene, which encodes a mitogen-responsive transcription factor. Activation of Egr-1 by v-Fps was insensitive to protein kinase C depletion, suggesting that a protein kinase C-indepen...
Topics
- Animals
- Avian Sarcoma Viruses
- Cell Line
- Cell Line, Transformed
- Cell Transformation, Viral
- DNA-Binding Proteins
- Early Growth Response Protein 1
- Enzyme Activation
- Fusion Proteins, gag-onc
- Gene Expression Regulation
- Immediate-Early Proteins
- Mutation
- Oncogene Protein p21(ras)