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Article

Ionizing radiation activates transcription of the EGR1 gene via CArG elements.

1 Nov 1992

Abstract excerpt

The present studies have examined the effects of ionizing radiation on control of the early growth response 1 (EGR1) gene. Exposure of human HL-525 cells to x-rays was associated with increases in EGR1 mRNA levels. Nuclear run-on assays showed that this effect is related at least in part to activation of EGR1 gene transcription. Sequences responsive to ionizing radiation-induced signals were determined by...

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PMID: 1332031
DOI: 10.1073/pnas.89.21.10149

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