Overlapping Egr-1 and Sp1 sites function in the regulation of transcription of the mouse thrombospondin 1 gene.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Overlapping Egr-1 and Sp1 sites function in the regulation of transcription of the mouse thrombospondin 1 gene.

The Journal of biological chemistry - 23 Dec 1994

Shingu T, Bornstein P

Abstract excerpt

We have evaluated the basis for the constitutive and serum-regulated expression of the mouse thrombospondin (TSP) gene in both transiently and stably transfected NIH-3T3 cells. Experiments with deleted and mutated mouse promoter/CAT constructs and gel mobility assays demonstrated that an Egr-1 binding site in the proximal promoter, flanked by overlapping GC boxes and an adjacent GC-rich region, functioned to...

Topics

3T3 Cells
Animals
Base Sequence
Blood
Chloramphenicol O-Acetyltransferase
DNA
DNA-Binding Proteins
Early Growth Response Protein 1
Humans
Immediate-Early Proteins
Membrane Glycoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Molecular Sequence Data

Mutation

Promoter Regions, Genetic

Sp1 Transcription Factor

Thrombospondins

Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 7798257

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7798257-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overlapping Egr-1 and Sp1 sites function in the regulation of transcription of the mouse thrombospondin 1 gene.PMID 7798257Read ↗

Thrombospondins: structure and regulation of expressionSemantic proximity Read ↗

Native and oxidized low density lipoprotein induction of tissue factor gene expression in smooth muscle cells is mediated by both Egr-1 and Sp1.Semantic proximity Read ↗

Regulation of the tissue factor geneSemantic proximity Read ↗

Transcriptional Regulation of the Tissue Factor Gene in Human Epithelial Cells Is Mediated by Sp1 and EGR-1Semantic proximity Read ↗

Egr-1 and Sp1 interact functionally with the 5-lipoxygenase promoter and its naturally occurring mutants.Semantic proximity Read ↗

Functional heterogeneity of mammalian TATA-box sequences revealed by interaction with a cell-specific enhancer.Semantic proximity Read ↗

Transcriptional regulation of the membrane-associated prostaglandin E2 synthase gene. Essential role of the transcription factor Egr-1.Semantic proximity Read ↗

Synergistic interactions between heterologous upstream activation elements and specific TATA sequences in a muscle-specific promoter.Semantic proximity Read ↗

Novel cis-acting elements in the human platelet-derived growth factor B-chain core promoter that mediate gene expression in cultured vascular endothelial cells.Semantic proximity Read ↗

Negative regulation of the vascular smooth muscle alpha-actin gene in fibroblasts and myoblasts: disruption of enhancer function by sequence-specific single-stranded-DNA-binding proteins.Semantic proximity Read ↗

In vivo analysis of retroviral enhancer mutations in hematopoietic cells: SP1/EGR1 and ETS/GATA motifs contribute to long terminal repeat specificity.Semantic proximity Read ↗

The functional domains of the murine Thy-1 gene promoter.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.