Article
A functional polymorphism within the MRP1 gene locus identified through its genomic signature of positive selection.
Human molecular genetics - 15 Jul 2005
Wang Zihua, Wang Baoshuang, Tang Kun, Lee Edmund J D, Chong Samuel S, Lee Caroline G L
Abstract excerpt
Searching for genomic evidence of positive selection has been hailed as an attractive strategy for identifying functional polymorphisms. Here, we demonstrate the feasibility of identifying functional polymorphism at the MRP1 gene locus using this strategy. The 190 kDa MRP1 protein is an efflux pump that regulates the accumulation of xenobiotics and drugs in cells. Functional sequence variations within this gene...
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