Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional characterization of non-synonymous single nucleotide polymorphisms in the gene encoding human multidrug resistance protein 1 (MRP1/ABCC1).

Pharmacogenetics and genomics - 1 Sept 2005

Létourneau Isabelle J, Deeley Roger G, Cole Susan P C

Abstract excerpt

The 190-kDa ATP-binding cassette (ABC) multidrug resistance protein 1 (MRP1) encoded by the MRP1/ABCC1 gene mediates the active cellular efflux of glucuronide, glutathione and sulfate conjugates. It can also confer resistance to a diverse spectrum of chemotherapeutic agents and transport a variety of toxicants. In the present study, we examined 10 MRP1/ABCC1 missense genetic variants [non-synonymous single...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Anions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biological Transport

Share to Estradiol

Share to Glucuronides

Share to Immunoblotting

Share to In Vitro Techniques

Share to Multidrug Resistance-Associated Proteins

Source

Identifiers

PMID: 16041243
DOI: 10.1097/01.fpc.0000173484.51807.48

Genes

ABCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional characterization of non-synonymous single nucleotide polymorphisms in the gene encoding human multidrug resistance protein 1 (MRP1/ABCC1).PMID 16041243Read ↗

Two polymorphic variants of ABCC1 selectively alter drug resistance and inhibitor sensitivity of the multidrug and organic anion transporter multidrug resistance protein 1.Semantic proximity Read ↗

Identification of human multidrug resistance protein 1 (MRP1) mutations and characterization of a G671V substitution.Semantic proximity Read ↗

Multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphism: from discovery to clinical application.Semantic proximity Read ↗

A naturally occurring mutation in MRP1 results in a selective decrease in organic anion transport and in increased doxorubicin resistance.Semantic proximity Read ↗

The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene.Semantic proximity Read ↗

Characterization and analyses of multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphisms in Chinese population.Semantic proximity Read ↗

Polymorphisms of MRP1 (ABCC1) and related ATP-dependent drug transportersSemantic proximity Read ↗

Functional analysis of nonsynonymous single nucleotide polymorphisms of multidrug resistance-associated protein 2 (ABCC2).Semantic proximity Read ↗

Functional and structural consequences of cysteine substitutions in the NH2 proximal region of the human multidrug resistance protein 1 (MRP1/ABCC1).Semantic proximity Read ↗

ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2.Semantic proximity Read ↗

Pharmacogenomics of ABC transporters and its role in cancer chemotherapy.Semantic proximity Read ↗

Identification of proline residues in the core cytoplasmic and transmembrane regions of multidrug resistance protein 1 (MRP1/ABCC1) important for transport function, substrate specificity, and nucleotide interactions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.