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Article

Identification of human multidrug resistance protein 1 (MRP1) mutations and characterization of a G671V substitution.

Journal of human genetics - 1 Jan 2001

Conrad S, Kauffmann H M, Ito K, Deeley R G, Cole S P, Schrenk D

Abstract excerpt

The multidrug resistance protein 1 (MRP1) belonging to the ATP-binding cassette (ABC) superfamily of transport proteins can confer resistance to multiple natural product drugs and methotrexate in human tumor cells. In addition, MRP1 is expressed in normal tissues acting as an efflux pump for glutathione, glucuronate, and sulfate conjugates and may thus influence the pharmacokinetic properties of many drugs. Using...

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PMID: 11721885
DOI: 10.1007/s100380170017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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