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Article

The influence of MDR1 polymorphisms on P-glycoprotein expression and function in humans.

Advanced drug delivery reviews - 18 Nov 2002

Fromm Martin F

Abstract excerpt

The MDR1 (ABCB1) gene product P-glycoprotein is a membrane protein, which functions as an ATP-dependent exporter of xenobiotics from cells. Its importance was first recognized because of its role in the development of multidrug resistance (MDR) of cultured tumor cells against various anticancer agents. It is now, however, well established that this transporter is not only expressed in tumor cells, but also in...

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Identifiers

PMID: 12406646
DOI: 10.1016/s0169-409x(02)00064-9

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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