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Article

Genomic evidence for recent positive selection at the human MDR1 gene locus.

Human molecular genetics - 15 Apr 2004

Tang Kun, Wong Li Peng, Lee Edmund J D, Chong Samuel S, Lee Caroline G L

Abstract excerpt

The MDR1 multidrug transporter regulates the traffic of drugs, peptides and xenobiotics into the body as well as sensitive tissues like the brain, germ cells and the developing fetus. Hence, it may influence an individual's response to drugs as well as his/her susceptibility to complex diseases in which environmental factors, especially xenobiotics, play a role. Polymorphisms within this gene, especially...

Topics

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ATP Binding Cassette Transporter, Subfamily B, Member 1
Drug Resistance, Multiple
Gene Frequency
Haplotypes
Linkage Disequilibrium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Selection, Genetic

Sequence Analysis, DNA

Source

Identifiers

PMID: 14976162
DOI: 10.1093/hmg/ddh099

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