Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Yeast as a tractable genetic system for functional studies of the insulin-degrading enzyme.

The Journal of biological chemistry - 29 Jul 2005

Kim Seonil, Lapham Andrea N, Freedman Christopher G K, Reed Tiffany L, Schmidt Walter K

Abstract excerpt

We have developed yeast as an expression and genetic system for functional studies of the insulin-degrading enzyme (IDE), which cleaves and inactivates certain small peptide molecules, including insulin and the neurotoxic A beta peptide. We show that heterologously expressed rat IDE is enzymatically active, as judged by the ability of IDE-containing yeast extracts to cleave insulin in vitro. We also show that IDE...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Genetic Techniques

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Haploidy

Share to Insulysin

Share to Mass Spectrometry

Share to Mating Factor

Share to Metalloendopeptidases

Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Source

Identifiers

PMID: 15944156
DOI: 10.1074/jbc.M414192200

Genes

IDE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Yeast as a tractable genetic system for functional studies of the insulin-degrading enzyme.PMID 15944156Read ↗

A common genetic system for functional studies of pitrilysin and related M16A proteases.Semantic proximity Read ↗

The Drosophila insulin-degrading enzyme restricts growth by modulating the PI3K pathway in a cell-autonomous manner.Semantic proximity Read ↗

Role of yeast insulin-degrading enzyme homologs in propheromone processing and bud site selection.Semantic proximity Read ↗

A yeast gene necessary for bud-site selection encodes a protein similar to insulin-degrading enzymes.Semantic proximity Read ↗

Rax1, a protein required for the establishment of the bipolar budding pattern in yeast.Semantic proximity Read ↗

Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway.Semantic proximity Read ↗

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones.Semantic proximity Read ↗

Ubiquitin is a novel substrate for human insulin-degrading enzyme.Semantic proximity Read ↗

Mutations in the yeast Hsp40 chaperone protein Ydj1 cause defects in Axl1 biogenesis and pro-a-factor processing.Semantic proximity Read ↗

Proteasome beta-type subunits: unequal roles of propeptides in core particle maturation and a hierarchy of active site function.Semantic proximity Read ↗

Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats.Semantic proximity Read ↗

The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.