Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway.

Molecular and cellular biology - 1 Dec 2001

Kwon Y T, Xia Z, Davydov I V, Lecker S H, Varshavsky A

Abstract excerpt

The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. In the yeast Saccharomyces cerevisiae, the UBR1-encoded ubiquitin ligase (E3) of the N-end rule pathway mediates the targeting of substrate proteins in part through binding to their destabilizing N-terminal residues. The functions of the yeast N-end rule pathway include fidelity of chromosome segregation and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue
Share to Amidohydrolases
Share to Fatty Acids

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Ligases

Share to Mice, Inbred Strains

Share to Starvation

Share to Ubiquitin-Conjugating Enzymes

Share to Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 11689692
DOI: 10.1128/MCB.21.23.8007-8021.2001
PMCID: PMC99968

Genes

UBR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway.PMID 11689692Read ↗

The mouse and human genes encoding the recognition component of the N-end rule pathwaySemantic proximity Read ↗

Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathwaySemantic proximity Read ↗

Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome).Semantic proximity Read ↗

A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.Semantic proximity Read ↗

Behavioral characterization of mice lacking the ubiquitin ligase UBR1 of the N-end rule pathway.Semantic proximity Read ↗

A recognition component of the ubiquitin system is required for peptide transport in Saccharomyces cerevisiae.Semantic proximity Read ↗

The recognition component of the N-end rule pathway.Semantic proximity Read ↗

Ablation of arginylation in the mouse N-end rule pathway: loss of fat, higher metabolic rate, damaged spermatogenesis, and neurological perturbations.Semantic proximity Read ↗

Ubiquitin ligases of the N-end rule pathway: assessment of mutations in UBR1 that cause the Johanson-Blizzard syndrome.Semantic proximity Read ↗

Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes.Semantic proximity Read ↗

<i>Ubc9</i> deletion in adipocytes causes lipoatrophy in miceSemantic proximity Read ↗

Functional integrity of the SEL1L-HRD1 complex is critical for ERAD and organismal viabilitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.