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Article

Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats.

Human molecular genetics - 1 Sept 2000

Fakhrai-Rad H, Nikoshkov A, Kamel A, Fernström M, Zierath J R, Norgren S, Luthman H, Galli J

Abstract excerpt

Genetic analysis of the diabetic GK rat has revealed several diabetes susceptibility loci. Congenic strains have been established for the major diabetes locus, Niddm1, by transfer of GK alleles onto the genome of the normoglycemic F344 rat. Niddm1 was dissected into two subloci, physically separated in the congenic strains Niddm1b and Niddm1i, each with at least one disease susceptibility gene. Here we have...

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Source

Identifiers

PMID: 10958757
DOI: 10.1093/hmg/9.14.2149

Genes

IDE

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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