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Article

Ubiquitin is a novel substrate for human insulin-degrading enzyme.

Journal of molecular biology - 25 Feb 2011

Ralat Luis A, Kalas Vasilios, Zheng Zhongzhou, Goldman Robert D, Sosnick Tobin R, Tang Wei-Jen

Abstract excerpt

Insulin-degrading enzyme (IDE) can degrade insulin and amyloid-β, peptides involved in diabetes and Alzheimer's disease, respectively. IDE selects its substrates based on size, charge, and flexibility. From these criteria, we predict that IDE can cleave and inactivate ubiquitin (Ub). Here, we sho...

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Identifiers

PMID: 21185309
DOI: 10.1016/j.jmb.2010.12.026
PMCID: PMC3064465

Genes

IDE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21185309-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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