Article
Role of yeast insulin-degrading enzyme homologs in propheromone processing and bud site selection.
Science (New York, N.Y.) - 20 Oct 1995
Adames N, Blundell K, Ashby M N, Boone C
Abstract excerpt
The Saccharomyces cerevisiae AXL1 gene product Axl1p shares homology with the insulin-degrading enzyme family of endoproteases. Yeast axl1 mutants showed a defect in a-factor pheromone secretion, and a probable site of processing by Axl1p was identified within the a-factor precursor. In addition,...
Topics
- Amino Acid Sequence
- Base Sequence
- Cell Membrane
- Cloning, Molecular
- Fungal Proteins
- Genes, Fungal
- Insulysin
- Lipoproteins
- Metalloendopeptidases
- Molecular Sequence Data
- Morphogenesis
- Mutagenesis, Site-Directed
- Phenotype
- Pheromones
- Protein Precursors
- Protein Processing, Post-Translational
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins