A yeast gene necessary for bud-site selection encodes a protein similar to insulin-degrading enzymes.

doi:10.1038/372567a0

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Article

A yeast gene necessary for bud-site selection encodes a protein similar to insulin-degrading enzymes.

Nature - 8 Dec 1994

Fujita A, Oka C, Arikawa Y, Katagai T, Tonouchi A, Kuhara S, Misumi Y

Abstract excerpt

Cells of the yeast Saccharomyces cerevisiae choose bud sites in a non-random spatial pattern that depends on mating type: axial for haploid cells and bipolar for a/alpha diploid cells. We identified a mutant yeast, axl 1, in which the budding pattern is altered from axial to bipolar. Expression of the AXL1 gene is repressed in a/alpha diploid cells. With the ectopic expression of AXL1, a/alpha cells exhibited an...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cell Division
DNA
Drosophila
Fungal Proteins
Genes, Fungal
Genes, Mating Type, Fungal
Humans
Insulin
Metalloendopeptidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Restriction Mapping

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Sequence Homology, Amino Acid

Source

Open in PubMed

Identifiers

PMID: 7990931
DOI: 10.1038/372567a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7990931-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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A yeast gene necessary for bud-site selection encodes a protein similar to insulin-degrading enzymes.PMID 7990931Read ↗

Rax1, a protein required for the establishment of the bipolar budding pattern in yeast.Semantic proximity Read ↗

Role of yeast insulin-degrading enzyme homologs in propheromone processing and bud site selection.Semantic proximity Read ↗

Genetic control of bud site selection in yeast by a set of gene products that constitute a morphogenetic pathway.Semantic proximity Read ↗

Subcellular localization of Axl1, the cell type-specific regulator of polarity.Semantic proximity Read ↗

Evidence for a branched pathway in the polarized cell division of Saccharomyces cerevisiae.Semantic proximity Read ↗

Aip3p/Bud6p, a yeast actin-interacting protein that is involved in morphogenesis and the selection of bipolar budding sites.Semantic proximity Read ↗

Yeast as a tractable genetic system for functional studies of the insulin-degrading enzyme.Semantic proximity Read ↗

O-Glycosylation of Axl2/Bud10p by Pmt4p is required for its stability, localization, and function in daughter cells.Semantic proximity Read ↗

BUD2 encodes a GTPase-activating protein for Bud1/Rsr1 necessary for proper bud-site selection in yeast.Semantic proximity Read ↗

Interactions among Rax1p, Rax2p, Bud8p, and Bud9p in marking cortical sites for bipolar bud-site selection in yeast.Semantic proximity Read ↗

Mutational and hyperexpression-induced disruption of bipolar budding in yeast.Semantic proximity Read ↗

A role for the actin cytoskeleton of Saccharomyces cerevisiae in bipolar bud-site selection.Semantic proximity Read ↗

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