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Article

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones.

Nature - 3 Jul 2014

Maianti Juan Pablo, McFedries Amanda, Foda Zachariah H, Kleiner Ralph E, Du Xiu Quan, Leissring Malcolm A, Tang Wei-Jen, Charron Maureen J, Seeliger Markus A, Saghatelian Alan, Liu David R

Abstract excerpt

Despite decades of speculation that inhibiting endogenous insulin degradation might treat type-2 diabetes, and the identification of IDE (insulin-degrading enzyme) as a diabetes susceptibility gene, the relationship between the activity of the zinc metalloprotein IDE and glucose homeostasis remains unclear. Although Ide(-/-) mice have elevated insulin levels, they exhibit impaired, rather than improved, glucose...

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Identifiers

PMID: 24847884
DOI: 10.1038/nature13297
PMCID: PMC4142213

Genes

IDE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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