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Article

Lymphoid tyrosine phosphatase (PTPN22/LYP) variant and Graves' disease in a Polish population: association and gene dose-dependent correlation with age of onset.

Clinical endocrinology - 1 Jun 2005

Skórka Agata, Bednarczuk Tomasz, Bar-Andziak Ewa, Nauman Janusz, Ploski Rafal

Abstract excerpt

OBJECTIVE: Susceptibility to Graves' disease (GD) is to a significant extent determined by genetic factors of which the best known are those associated with the HLA and the CTLA4 locus. Recently, two studies on British Caucasians reported that a single nucleotide polymorphism, 1858 C > T in PTPN22, encoding Arg620Trp in the lymphoid protein tyrosine phosphatase (LYP), which is a negative regulator of T-cell...

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Source

Identifiers

PMID: 15943829
DOI: 10.1111/j.1365-2265.2005.02279.x

Genes

PTPN22
CTLA4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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