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Article

Associations of protein tyrosine phosphatase nonreceptor 22 (PTPN22) gene polymorphisms with susceptibility to Graves' disease in a Japanese population.

Thyroid : official journal of the American Thyroid Association - 1 Jun 2008

Ichimura Michiko, Kaku Hiroo, Fukutani Tomoka, Koga Hirohisa, Mukai Tokunori, Miyake Ikuyo, Yamada Kentaro, Koda Yoshiro, Hiromatsu Yuji

Abstract excerpt

BACKGROUND: The polymorphism of the protein tyrosine phosphatase nonreceptor 22 (PTPN22) gene, which encodes an important negative regulator of T cell activation, has been reported to be associated with susceptibility to Graves' disease (GD) in Caucasians. The objective of this study was to investigate whether PTPN22 gene polymorphisms confer susceptibility to GD and Graves' ophthalmopathy (GO) in a Japanese...

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Source

Identifiers

PMID: 18578611
DOI: 10.1089/thy.2007.0353

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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