Article
Oncogene amplification in the proximal part of chromosome 6 in rat endometrial adenocarcinoma as revealed by combined BAC/PAC FISH, chromosome painting, zoo-FISH, and allelotyping.
Genes, chromosomes & cancer - 1 Oct 2005
Adamovic Tatjana, Trossö Fredrik, Roshani Leyla, Andersson Lars, Petersen Greta, Rajaei Saide, Helou Khalil, Levan Göran
Abstract excerpt
The inbred BDII rat is a valuable experimental model for the genetic analysis of endometrial adenocarcinoma (EAC). One common aberration detected by comparative genomic hybridization in rat EAC was gain/amplification affecting the proximal part of rat chromosome 6 (RNO6). We applied rat and mouse chromosome painting probes onto tumor cell metaphase preparations in order to detect and characterize gross RNO6...
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