Article
Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype.
PloS one - 1 Jan 2016
Kanemoto Kazuhiro, Fukuta Katsuhiro, Kawai Noriyasu, Tozawa Keiichi, Ochiai Masako, Okamoto Koji, Ohnami Sumiko, Sakamoto Hiromi, Yoshida Teruhiko, Kanai Yae, Katoh Masaru, Yasui Takahiro, Kohri Kenjiro, Kakizoe Tadao, Nakagama Hitoshi
Abstract excerpt
Non-muscle invasive (superficial) bladder cancer is a low-grade malignancy with good prognosis, while muscle invasive (invasive) bladder cancer is a high-grade malignancy with poor prognosis. N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) induces superficial bladder cancers with papillary morphology in rats and invasive bladder cancers with infiltrating phenotype in mice. In this study, we analyzed genomic...
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