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Article

Rearrangement and allelic imbalance on chromosome 5 leads to homozygous deletions in the CDKN2A/2B tumor suppressor gene region in rat endometrial cancer.

Cancer genetics and cytogenetics - 1 Jul 2008

Adamovic Tatjana, Hamta Ahmad, Roshani Leyla, Lü Xuchun, Röhme Dan, Helou Khalil, Klinga-Levan Karin, Levan Göran

Abstract excerpt

The inbred BDII rat is a valuable experimental model for the genetic analysis of hormone-dependent endometrial adenocarcinoma (EAC). One common aberration detected previously by comparative genomic hybridization in rat EAC is loss affecting mostly the middle part of rat chromosome 5 (RNO5). First, we applied an RNO5-specific painting probe and four region-specific gene probes onto tumor cell metaphases from 21...

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PMID: 18558284
DOI: 10.1016/j.cancergencyto.2008.02.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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