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Article

Gene Amplification Is a Mechanism of <i>Six1</i> Overexpression in Breast Cancer

1 Apr 2005

Abstract excerpt

The Six1 homeoprotein plays a critical role in expanding progenitor populations during normal development via its stimulation of proliferation and inhibition of apoptosis. Overexpression of Six1 is observed in several tumor types, suggesting that when expressed out of context, Six1 may contribute to tumorigenesis by reinstating properties normally conveyed on developing cells. Indeed, Six1 contributes to tumor...

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PMID: 15805264
DOI: 10.1158/0008-5472.can-04-4286

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Related research

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Gene Amplification Is a Mechanism of <i>Six1</i> Overexpression in Breast CancerPMID 15805264Read ↗

Six1 Overexpression in Mammary Cells Induces Genomic Instability and Is Sufficient for Malignant TransformationSemantic proximity Read ↗

SIX1 amplification modulates stemness and tumorigenesis in breast cancerSemantic proximity Read ↗

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SIX1 Down-Regulation Influence Drug Resistance, Epithelial-Mesenchymal Transcription Factors and Self-Renewal Capacity in Hepatocellular CarcinomaSemantic proximity Read ↗

Six1 promotes epithelial-mesenchymal transition and malignant conversion in human papillomavirus type 16-immortalized human keratinocytesSemantic proximity Read ↗

SIX1 reprograms myogenic transcription factors to maintain the rhabdomyosarcoma undifferentiated stateSemantic proximity Read ↗

Six1 regulates leukemia stem cell maintenance in acute myeloid leukemiaSemantic proximity Read ↗

SIX1 Reprograms Myogenic Transcription Factors to Maintain the Rhabdomyosarcoma undifferentiated stateSemantic proximity Read ↗

Six1 Overexpression in Ovarian Carcinoma Causes Resistance to TRAIL-Mediated Apoptosis and Is Associated with Poor SurvivalSemantic proximity Read ↗

The role of Six1 signaling in paclitaxel-dependent apoptosis in MCF-7 cell lineSemantic proximity Read ↗

SIX1 Activates STAT3 Signaling to Promote the Proliferation of Thyroid Carcinoma via EYA1Semantic proximity Read ↗

SIX1 Regulates Aberrant Endometrial Epithelial Cell Differentiation and Cancer Latency Following Developmental Estrogenic Chemical ExposureSemantic proximity Read ↗

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