Four regions of allelic imbalance on 17q12-qter associated with high-grade breast tumors.

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Article

Four regions of allelic imbalance on 17q12-qter associated with high-grade breast tumors.

Genes, chromosomes & cancer - 1 Dec 1997

Plummer S J, Paris M J, Myles J, Tubbs R, Crowe J, Casey G

Abstract excerpt

Rearrangements or loss of chromosome 17 are frequent events in breast tumors. Chromosome 17 contains at least four genes implicated in breast cancer (TP53, ERBB2 (Her2/neu), BRCA1, and NM23), as well as other putative tumor suppressor genes and oncogenes implicated in loss of heterozygosity or al...

Topics

Alleles
Breast Neoplasms
Carcinoma in Situ
Carcinoma, Ductal, Breast
Chromosome Deletion
Chromosomes, Human, Pair 17
DNA, Neoplasm
Female
Gene Expression
Humans
Immunohistochemistry
Loss of Heterozygosity
Microsatellite Repeats
Polymerase Chain Reaction
Repetitive Sequences, Nucleic Acid

Source

Open in PubMed

Identifiers

PMID: 9408751

Genes

BRCA1
ERBB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9408751-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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