Mutation analysis of the MCHR1 gene in human obesity.

doi:10.1530/eje.1.01917

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Article

Mutation analysis of the MCHR1 gene in human obesity.

European journal of endocrinology - 1 Jun 2005

Wermter Anne-Kathrin, Reichwald Kathrin, Büch Thomas, Geller Frank, Platzer Cornelia, Huse Klaus, Hess Claudia, Remschmidt Helmut, Gudermann Thomas, Preibisch Gerald, Siegfried Wolfgang, Goldschmidt Hans-Peter, Li Wei-Dong, Price R Arlen, Biebermann Heike, Krude Heiko, Vollmert Caren, Wichmann H-Erich, Illig Thomas, Sørensen Thorkild I A, Astrup Arne, Larsen Lesli Hingstrup, Pedersen Oluf, Eberlé Delphine, Clément Karine, Blundell John, Wabitsch Martin, Schäfer Helmut, Platzer Matthias, Hinney Anke, Hebebrand Johannes

Abstract excerpt

OBJECTIVE: The importance of the melanin-concentrating hormone (MCH) system for regulation of energy homeostasis and body weight has been demonstrated in rodents. We analysed the human MCH receptor 1 gene (MCHR1) with respect to human obesity. DESIGN: This consisted of genomic screening of 13.4 kb encompassing the MCHR1 in extremely obese German children and adolescents and association analyses for two coding...

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PMID: 15941924
DOI: 10.1530/eje.1.01917

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MCHR1

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