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Article

Melanin-concentrating hormone receptor mutations and human obesity: functional analysis.

Obesity research - 1 May 2004

Gibson William T, Pissios Pavlos, Trombly Daniel J, Luan Jian'an, Keogh Julia, Wareham Nicholas J, Maratos-Flier Eleftheria, O'Rahilly Stephen, Farooqi I Sadaf

Abstract excerpt

Melanin-concentrating hormone (MCH), a neuropeptide highly expressed in the lateral hypothalamus, has an important role in the regulation of energy balance and body weight in rodents. We examined whether mutations in the two known MCH receptors might be associated with obesity-related phenotypes...

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Source

Identifiers

PMID: 15166293
DOI: 10.1038/oby.2004.89

Genes

MCHR1
MCHR2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15166293-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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